Basic Information
Gene ID ENSAMEG00000011072
Gene Name ESR1
Full Name Uncharacterized protein
Organism Ailuropoda melanoleuca [9646]

Cross Reference
UniProt G1LX33 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSAMEP00000011636 Gene3D G3DSA:1.10.565.10 IPR008946 163 402 1.30e-101 Nuclear hormone receptor, ligand-binding
ENSAMEP00000011636 Gene3D G3DSA:1.10.565.10 IPR008946 91 121 1.30e-101 Nuclear hormone receptor, ligand-binding
ENSAMEP00000011636 Gene3D G3DSA:3.30.50.10 IPR013088 37 90 6.40e-28 Zinc finger, NHR/GATA-type
ENSAMEP00000011636 Pfam PF00104 IPR000536 183 378 9.60e-29 Nuclear hormone receptor, ligand-binding, core
ENSAMEP00000011636 Pfam PF00105 IPR001628 36 104 1.50e-31 Zinc finger, nuclear hormone receptor-type
ENSAMEP00000011636 Pfam PF02159 IPR001292 2 33 3.60e-05 Oestrogen receptor
ENSAMEP00000011636 Pfam PF12743 IPR024736 406 449 3.50e-21 Oestrogen-type nuclear receptor final C-terminal domain
ENSAMEP00000011636 PIRSF PIRSF002527 IPR024178 1 444 1.70e-237 Oestrogen receptor/oestrogen-related receptor
ENSAMEP00000011636 PRINTS PR00047 IPR001628 37 53 3.00e-17 Zinc finger, nuclear hormone receptor-type
ENSAMEP00000011636 PRINTS PR00047 IPR001628 53 68 3.00e-17 Zinc finger, nuclear hormone receptor-type
ENSAMEP00000011636 PRINTS PR00047 IPR001628 86 94 3.00e-17 Zinc finger, nuclear hormone receptor-type
ENSAMEP00000011636 PRINTS PR00047 IPR001628 94 102 3.00e-17 Zinc finger, nuclear hormone receptor-type
ENSAMEP00000011636 PRINTS PR00398 IPR001723 201 222 1.60e-27 Steroid hormone receptor
ENSAMEP00000011636 PRINTS PR00398 IPR001723 222 238 1.60e-27 Steroid hormone receptor
ENSAMEP00000011636 PRINTS PR00398 IPR001723 290 305 1.60e-27 Steroid hormone receptor
ENSAMEP00000011636 PRINTS PR00398 IPR001723 360 377 1.60e-27 Steroid hormone receptor
ENSAMEP00000011636 PRINTS PR00398 IPR001723 98 108 1.60e-27 Steroid hormone receptor
ENSAMEP00000011636 ProSitePatterns PS00031 IPR001628 37 63 - Zinc finger, nuclear hormone receptor-type
ENSAMEP00000011636 ProSiteProfiles PS51030 IPR001628 34 109 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSAMEP00000011636 SMART SM00399 IPR001628 34 105 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSAMEP00000011636 SMART SM00430 IPR000536 200 372 3.80e-38 Nuclear hormone receptor, ligand-binding, core
ENSAMEP00000011636 SUPERFAMILY SSF48508 IPR008946 154 401 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSAMEP00000011636 SUPERFAMILY SSF48508 IPR008946 87 113 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSAMEP00000011636 PF00105 9e-32 zf-C4 Zinc finger, C4 type (two domains)
ENSAMEP00000011636 PF00104 5.3e-29 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSAMEP00000011636 PF12743 2e-21 ESR1_C Oestrogen-type nuclear receptor final C-terminal
ENSAMEP00000011636 PF02159 1.6e-05 Oest_recep Oestrogen receptor

Gene Ontology Annotation
Protein Entry Name Space Description
ENSAMEP00000011636 GO:0006351 biological_process transcription, DNA-templated
ENSAMEP00000011636 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSAMEP00000011636 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSAMEP00000011636 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSAMEP00000011636 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSAMEP00000011636 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSAMEP00000011636 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSAMEP00000011636 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSAMEP00000011636 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSAMEP00000011636 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSAMEP00000011636 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSAMEP00000011636 GO:0071392 biological_process cellular response to estradiol stimulus
ENSAMEP00000011636 GO:0005634 cellular_component nucleus
ENSAMEP00000011636 GO:0005794 cellular_component Golgi apparatus
ENSAMEP00000011636 GO:0005886 cellular_component plasma membrane
ENSAMEP00000011636 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSAMEP00000011636 GO:0003707 molecular_function steroid hormone receptor activity
ENSAMEP00000011636 GO:0005496 molecular_function steroid binding
ENSAMEP00000011636 GO:0008270 molecular_function zinc ion binding
ENSAMEP00000011636 GO:0030284 molecular_function estrogen receptor activity
ENSAMEP00000011636 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 9103 Meleagris gallopavo 100542782
61853 Nomascus leucogenys 100580202 10029 Cricetulus griseus 100768474
9597 Pan paniscus 100980011 39432 Saimiri boliviensis 101034130
8083 Xiphophorus maculatus 102235986 13735 Pelodiscus sinensis 102456765
10090 Mus musculus 13982 9606 Homo sapiens 2099
9615 Canis familiaris 403640 28377 Anolis carolinensis ENSACAG00000006213
9483 Callithrix jacchus 100385918 10141 Cavia porcellus 100713276
9669 Mustela putorius furo 101690352 9031 Gallus gallus ENSGALG00000012973
31033 Takifugu rubripes ENSTRUG00000018219 9913 Bos taurus ENSBTAG00000007159
7955 Danio rerio ENSDARG00000004111 10020 Dipodomys ordii ENSDORG00000010443
9796 Equus caballus ENSECAG00000022441 9365 Erinaceus europaeus ENSEEUG00000000828
9371 Echinops telfairi ENSETEG00000006131 9685 Felis catus ENSFCAG00000031492
69293 Gasterosteus aculeatus ENSGACG00000008711 9595 Gorilla gorilla ENSGGOG00000009678
8049 Gadus morhua ENSGMOG00000014898 9315 Macropus eugenii ENSMEUG00000003564
30608 Microcebus murinus ENSMICG00000007592 59463 Myotis lucifugus ENSMLUG00000014181
9258 Ornithorhynchus anatinus ENSOANG00000015561 30611 Otolemur garnettii ENSOGAG00000012580
9978 Ochotona princeps ENSOPRG00000012663 8090 Oryzias latipes ENSORLG00000014514
132908 Pteropus vampyrus ENSPVAG00000001923 42254 Sorex araneus ENSSARG00000004419
43179 Ictidomys tridecemlineatus ENSSTOG00000006748 37347 Tupaia belangeri ENSTBEG00000005946
59729 Taeniopygia guttata ENSTGUG00000011249 99883 Tetraodon nigroviridis ENSTNIG00000012264
9478 Tarsius syrichta ENSTSYG00000006280 9739 Tursiops truncatus ENSTTRG00000002996
30538 Vicugna pacos ENSVPAG00000001185 8364 Xenopus tropicalis ENSXETG00000012364