Basic Information
Gene ID ENSTGUG00000011249
Gene Name ESR1
Full Name Estrogen receptor
Organism Taeniopygia guttata [59729]

Cross Reference
UniProt H0ZLY1 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSTGUP00000011604 Gene3D G3DSA:1.10.565.10 IPR008946 233 263 1.70e-97 Nuclear hormone receptor, ligand-binding
ENSTGUP00000011604 Gene3D G3DSA:1.10.565.10 IPR008946 305 542 1.70e-97 Nuclear hormone receptor, ligand-binding
ENSTGUP00000011604 Gene3D G3DSA:3.30.50.10 IPR013088 179 232 9.50e-28 Zinc finger, NHR/GATA-type
ENSTGUP00000011604 Pfam PF00104 IPR000536 322 518 8.50e-29 Nuclear hormone receptor, ligand-binding, core
ENSTGUP00000011604 Pfam PF00105 IPR001628 178 246 2.20e-31 Zinc finger, nuclear hormone receptor-type
ENSTGUP00000011604 Pfam PF02159 IPR001292 42 175 1.60e-53 Oestrogen receptor
ENSTGUP00000011604 Pfam PF12743 IPR024736 546 589 3.10e-20 Oestrogen-type nuclear receptor final C-terminal domain
ENSTGUP00000011604 PIRSF PIRSF002527 IPR024178 42 583 6.00e-291 Oestrogen receptor/oestrogen-related receptor
ENSTGUP00000011604 PIRSF PIRSF500101 IPR001292 1 589 0.00e-00 Oestrogen receptor
ENSTGUP00000011604 PRINTS PR00047 IPR001628 179 195 7.90e-17 Zinc finger, nuclear hormone receptor-type
ENSTGUP00000011604 PRINTS PR00047 IPR001628 195 210 7.90e-17 Zinc finger, nuclear hormone receptor-type
ENSTGUP00000011604 PRINTS PR00047 IPR001628 228 236 7.90e-17 Zinc finger, nuclear hormone receptor-type
ENSTGUP00000011604 PRINTS PR00047 IPR001628 236 244 7.90e-17 Zinc finger, nuclear hormone receptor-type
ENSTGUP00000011604 PRINTS PR00398 IPR001723 240 250 5.50e-27 Steroid hormone receptor
ENSTGUP00000011604 PRINTS PR00398 IPR001723 343 364 5.50e-27 Steroid hormone receptor
ENSTGUP00000011604 PRINTS PR00398 IPR001723 364 380 5.50e-27 Steroid hormone receptor
ENSTGUP00000011604 PRINTS PR00398 IPR001723 432 447 5.50e-27 Steroid hormone receptor
ENSTGUP00000011604 PRINTS PR00398 IPR001723 500 517 5.50e-27 Steroid hormone receptor
ENSTGUP00000011604 PRINTS PR00543 IPR001292 109 125 3.00e-75 Oestrogen receptor
ENSTGUP00000011604 PRINTS PR00543 IPR001292 126 145 3.00e-75 Oestrogen receptor
ENSTGUP00000011604 PRINTS PR00543 IPR001292 147 166 3.00e-75 Oestrogen receptor
ENSTGUP00000011604 PRINTS PR00543 IPR001292 26 43 3.00e-75 Oestrogen receptor
ENSTGUP00000011604 PRINTS PR00543 IPR001292 45 62 3.00e-75 Oestrogen receptor
ENSTGUP00000011604 PRINTS PR00543 IPR001292 6 24 3.00e-75 Oestrogen receptor
ENSTGUP00000011604 PRINTS PR00543 IPR001292 66 81 3.00e-75 Oestrogen receptor
ENSTGUP00000011604 PRINTS PR00543 IPR001292 91 105 3.00e-75 Oestrogen receptor
ENSTGUP00000011604 ProSitePatterns PS00031 IPR001628 179 205 - Zinc finger, nuclear hormone receptor-type
ENSTGUP00000011604 ProSiteProfiles PS51030 IPR001628 176 251 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSTGUP00000011604 SMART SM00399 IPR001628 176 247 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSTGUP00000011604 SMART SM00430 IPR000536 342 512 3.50e-37 Nuclear hormone receptor, ligand-binding, core
ENSTGUP00000011604 SUPERFAMILY SSF48508 IPR008946 229 255 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSTGUP00000011604 SUPERFAMILY SSF48508 IPR008946 296 541 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSTGUP00000011604 PF02159 0 Oest_recep Oestrogen receptor
ENSTGUP00000011604 PF00105 1.2e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSTGUP00000011604 PF00104 5.1e-29 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSTGUP00000011604 PF12743 1.3e-20 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSTGUP00000011604 GO:0006351 biological_process transcription, DNA-templated
ENSTGUP00000011604 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSTGUP00000011604 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSTGUP00000011604 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSTGUP00000011604 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSTGUP00000011604 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSTGUP00000011604 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSTGUP00000011604 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSTGUP00000011604 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSTGUP00000011604 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSTGUP00000011604 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSTGUP00000011604 GO:0071392 biological_process cellular response to estradiol stimulus
ENSTGUP00000011604 GO:0005634 cellular_component nucleus
ENSTGUP00000011604 GO:0005794 cellular_component Golgi apparatus
ENSTGUP00000011604 GO:0005886 cellular_component plasma membrane
ENSTGUP00000011604 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSTGUP00000011604 GO:0003707 molecular_function steroid hormone receptor activity
ENSTGUP00000011604 GO:0005496 molecular_function steroid binding
ENSTGUP00000011604 GO:0008270 molecular_function zinc ion binding
ENSTGUP00000011604 GO:0030284 molecular_function estrogen receptor activity
ENSTGUP00000011604 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9598 Pan troglodytes 452964 8049 Gadus morhua ENSGMOG00000014898
9315 Macropus eugenii ENSMEUG00000003564 132908 Pteropus vampyrus ENSPVAG00000001923
9823 Sus scrofa ENSSSCG00000005109 37347 Tupaia belangeri ENSTBEG00000005946
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 9483 Callithrix jacchus 100385918
9601 Pongo abelii 100459579 9103 Meleagris gallopavo 100542782
61853 Nomascus leucogenys 100580202 10141 Cavia porcellus 100713276
10029 Cricetulus griseus 100768474 9597 Pan paniscus 100980011
39432 Saimiri boliviensis 101034130 9669 Mustela putorius furo 101690352
8083 Xiphophorus maculatus 102235986 7897 Latimeria chalumnae 102366308
13735 Pelodiscus sinensis 102456765 10090 Mus musculus 13982
9606 Homo sapiens 2099 9615 Canis familiaris 403640
9544 Macaca mulatta 574110 28377 Anolis carolinensis ENSACAG00000006213
9646 Ailuropoda melanoleuca ENSAMEG00000011072 9913 Bos taurus ENSBTAG00000007159
9358 Choloepus hoffmanni ENSCHOG00000012987 7955 Danio rerio ENSDARG00000004111
9361 Dasypus novemcinctus ENSDNOG00000013868 10020 Dipodomys ordii ENSDORG00000010443
9796 Equus caballus ENSECAG00000022441 9365 Erinaceus europaeus ENSEEUG00000000828
9371 Echinops telfairi ENSETEG00000006131 9685 Felis catus ENSFCAG00000031492
69293 Gasterosteus aculeatus ENSGACG00000008711 9031 Gallus gallus ENSGALG00000012973
9595 Gorilla gorilla ENSGGOG00000009678 9785 Loxodonta africana ENSLAFG00000017799
30608 Microcebus murinus ENSMICG00000007592 59463 Myotis lucifugus ENSMLUG00000014181
9258 Ornithorhynchus anatinus ENSOANG00000015561 30611 Otolemur garnettii ENSOGAG00000012580
8128 Oreochromis niloticus ENSONIG00000013354 9978 Ochotona princeps ENSOPRG00000012663
8090 Oryzias latipes ENSORLG00000014514 9813 Procavia capensis ENSPCAG00000011157
7757 Petromyzon marinus ENSPMAG00000008530 10116 Rattus norvegicus ENSRNOG00000019358
42254 Sorex araneus ENSSARG00000004419 9305 Sarcophilus harrisii ENSSHAG00000008174
43179 Ictidomys tridecemlineatus ENSSTOG00000006748 99883 Tetraodon nigroviridis ENSTNIG00000012264
31033 Takifugu rubripes ENSTRUG00000018219 9478 Tarsius syrichta ENSTSYG00000006280
9739 Tursiops truncatus ENSTTRG00000002996 30538 Vicugna pacos ENSVPAG00000001185
8364 Xenopus tropicalis ENSXETG00000012364