Basic Information
Gene ID 13982 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Esr1; Esr, Estr, Estra, Nr3a1
Full Name Estrogen receptor
Organism Mus musculus [10090]

Cross Reference
UniProt P19785 UniGene Mm.9213
PDB NULL OMIM NULL
KEGG mmu:13982 UCSC uc007egu.2

Protein Interactions
DIP NULL
IntAct P19785
MINT MINT-2835181
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMUSP00000070070 Gene3D G3DSA:1.10.565.10 IPR008946 243 273 1.70e-100 Nuclear hormone receptor, ligand-binding
ENSMUSP00000070070 Gene3D G3DSA:1.10.565.10 IPR008946 315 552 1.70e-100 Nuclear hormone receptor, ligand-binding
ENSMUSP00000070070 Gene3D G3DSA:3.30.50.10 IPR013088 189 242 9.70e-28 Zinc finger, NHR/GATA-type
ENSMUSP00000070070 Pfam PF00104 IPR000536 332 528 2.70e-29 Nuclear hormone receptor, ligand-binding, core
ENSMUSP00000070070 Pfam PF00105 IPR001628 188 256 2.20e-31 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000070070 Pfam PF02159 IPR001292 42 185 5.70e-54 Oestrogen receptor
ENSMUSP00000070070 Pfam PF12743 IPR024736 556 599 1.20e-20 Oestrogen-type nuclear receptor final C-terminal domain
ENSMUSP00000070070 PIRSF PIRSF002527 IPR024178 42 594 7.00e-304 Oestrogen receptor/oestrogen-related receptor
ENSMUSP00000070070 PIRSF PIRSF500101 IPR001292 1 599 0.00e-00 Oestrogen receptor
ENSMUSP00000070070 PRINTS PR00047 IPR001628 189 205 8.40e-17 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000070070 PRINTS PR00047 IPR001628 205 220 8.40e-17 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000070070 PRINTS PR00047 IPR001628 238 246 8.40e-17 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000070070 PRINTS PR00047 IPR001628 246 254 8.40e-17 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000070070 PRINTS PR00398 IPR001723 250 260 1.70e-26 Steroid hormone receptor
ENSMUSP00000070070 PRINTS PR00398 IPR001723 353 374 1.70e-26 Steroid hormone receptor
ENSMUSP00000070070 PRINTS PR00398 IPR001723 374 390 1.70e-26 Steroid hormone receptor
ENSMUSP00000070070 PRINTS PR00398 IPR001723 442 457 1.70e-26 Steroid hormone receptor
ENSMUSP00000070070 PRINTS PR00398 IPR001723 510 527 1.70e-26 Steroid hormone receptor
ENSMUSP00000070070 PRINTS PR00543 IPR001292 101 115 3.20e-83 Oestrogen receptor
ENSMUSP00000070070 PRINTS PR00543 IPR001292 119 135 3.20e-83 Oestrogen receptor
ENSMUSP00000070070 PRINTS PR00543 IPR001292 136 155 3.20e-83 Oestrogen receptor
ENSMUSP00000070070 PRINTS PR00543 IPR001292 157 176 3.20e-83 Oestrogen receptor
ENSMUSP00000070070 PRINTS PR00543 IPR001292 26 43 3.20e-83 Oestrogen receptor
ENSMUSP00000070070 PRINTS PR00543 IPR001292 45 62 3.20e-83 Oestrogen receptor
ENSMUSP00000070070 PRINTS PR00543 IPR001292 6 24 3.20e-83 Oestrogen receptor
ENSMUSP00000070070 PRINTS PR00543 IPR001292 74 89 3.20e-83 Oestrogen receptor
ENSMUSP00000070070 ProSitePatterns PS00031 IPR001628 189 215 - Zinc finger, nuclear hormone receptor-type
ENSMUSP00000070070 ProSiteProfiles PS51030 IPR001628 186 261 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000070070 SMART SM00399 IPR001628 186 257 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000070070 SMART SM00430 IPR000536 352 522 4.00e-38 Nuclear hormone receptor, ligand-binding, core
ENSMUSP00000070070 SUPERFAMILY SSF48508 IPR008946 239 265 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSMUSP00000070070 SUPERFAMILY SSF48508 IPR008946 306 551 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMUSP00000070070 PF02159 0 Oest_recep Oestrogen receptor
ENSMUSP00000070070 PF00105 1.4e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSMUSP00000070070 PF00104 1.6e-29 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSMUSP00000070070 PF12743 6.5e-21 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMUSP00000070070 GO:0006351 biological_process transcription, DNA-templated
ENSMUSP00000070070 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSMUSP00000070070 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSMUSP00000070070 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSMUSP00000070070 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSMUSP00000070070 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSMUSP00000070070 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSMUSP00000070070 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSMUSP00000070070 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSMUSP00000070070 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSMUSP00000070070 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSMUSP00000070070 GO:0071392 biological_process cellular response to estradiol stimulus
ENSMUSP00000070070 GO:0005634 cellular_component nucleus
ENSMUSP00000070070 GO:0005794 cellular_component Golgi apparatus
ENSMUSP00000070070 GO:0005886 cellular_component plasma membrane
ENSMUSP00000070070 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSMUSP00000070070 GO:0003707 molecular_function steroid hormone receptor activity
ENSMUSP00000070070 GO:0005496 molecular_function steroid binding
ENSMUSP00000070070 GO:0008270 molecular_function zinc ion binding
ENSMUSP00000070070 GO:0030284 molecular_function estrogen receptor activity
ENSMUSP00000070070 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 9597 Pan paniscus 100980011
9483 Callithrix jacchus 100385918 9103 Meleagris gallopavo 100542782
61853 Nomascus leucogenys 100580202 10141 Cavia porcellus 100713276
10029 Cricetulus griseus 100768474 39432 Saimiri boliviensis 101034130
9669 Mustela putorius furo 101690352 8083 Xiphophorus maculatus 102235986
13735 Pelodiscus sinensis 102456765 9606 Homo sapiens 2099
9646 Ailuropoda melanoleuca ENSAMEG00000011072 7955 Danio rerio ENSDARG00000004111
9371 Echinops telfairi ENSETEG00000006131 9685 Felis catus ENSFCAG00000031492
69293 Gasterosteus aculeatus ENSGACG00000008711 9031 Gallus gallus ENSGALG00000012973
30608 Microcebus murinus ENSMICG00000007592 59463 Myotis lucifugus ENSMLUG00000014181
30611 Otolemur garnettii ENSOGAG00000012580 8090 Oryzias latipes ENSORLG00000014514
10116 Rattus norvegicus ENSRNOG00000019358 42254 Sorex araneus ENSSARG00000004419
31033 Takifugu rubripes ENSTRUG00000018219 9478 Tarsius syrichta ENSTSYG00000006280
9739 Tursiops truncatus ENSTTRG00000002996 8364 Xenopus tropicalis ENSXETG00000012364
9615 Canis familiaris 403640 28377 Anolis carolinensis ENSACAG00000006213
9913 Bos taurus ENSBTAG00000007159 10020 Dipodomys ordii ENSDORG00000010443
9796 Equus caballus ENSECAG00000022441 9365 Erinaceus europaeus ENSEEUG00000000828
9595 Gorilla gorilla ENSGGOG00000009678 8049 Gadus morhua ENSGMOG00000014898
9315 Macropus eugenii ENSMEUG00000003564 9258 Ornithorhynchus anatinus ENSOANG00000015561
8128 Oreochromis niloticus ENSONIG00000013354 9978 Ochotona princeps ENSOPRG00000012663
132908 Pteropus vampyrus ENSPVAG00000001923 43179 Ictidomys tridecemlineatus ENSSTOG00000006748
37347 Tupaia belangeri ENSTBEG00000005946 59729 Taeniopygia guttata ENSTGUG00000011249
99883 Tetraodon nigroviridis ENSTNIG00000012264 30538 Vicugna pacos ENSVPAG00000001185