Basic Information
Gene ID 100027187
Gene Name ESR1
Full Name Estrogen receptor
Organism Monodelphis domestica [13616]

Cross Reference
UniProt F7CHI9 UniGene NULL
PDB NULL OMIM NULL
KEGG mdo:100027187 UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMODP00000020873 Gene3D G3DSA:1.10.565.10 IPR008946 234 264 2.50e-100 Nuclear hormone receptor, ligand-binding
ENSMODP00000020873 Gene3D G3DSA:1.10.565.10 IPR008946 306 543 2.50e-100 Nuclear hormone receptor, ligand-binding
ENSMODP00000020873 Gene3D G3DSA:3.30.50.10 IPR013088 180 233 9.50e-28 Zinc finger, NHR/GATA-type
ENSMODP00000020873 Pfam PF00104 IPR000536 322 519 9.40e-30 Nuclear hormone receptor, ligand-binding, core
ENSMODP00000020873 Pfam PF00105 IPR001628 179 247 2.20e-31 Zinc finger, nuclear hormone receptor-type
ENSMODP00000020873 Pfam PF02159 IPR001292 42 176 1.60e-51 Oestrogen receptor
ENSMODP00000020873 Pfam PF12743 IPR024736 547 589 1.90e-21 Oestrogen-type nuclear receptor final C-terminal domain
ENSMODP00000020873 PIRSF PIRSF002527 IPR024178 42 584 3.90e-296 Oestrogen receptor/oestrogen-related receptor
ENSMODP00000020873 PIRSF PIRSF500101 IPR001292 1 589 0.00e-00 Oestrogen receptor
ENSMODP00000020873 PRINTS PR00047 IPR001628 180 196 7.90e-17 Zinc finger, nuclear hormone receptor-type
ENSMODP00000020873 PRINTS PR00047 IPR001628 196 211 7.90e-17 Zinc finger, nuclear hormone receptor-type
ENSMODP00000020873 PRINTS PR00047 IPR001628 229 237 7.90e-17 Zinc finger, nuclear hormone receptor-type
ENSMODP00000020873 PRINTS PR00047 IPR001628 237 245 7.90e-17 Zinc finger, nuclear hormone receptor-type
ENSMODP00000020873 PRINTS PR00398 IPR001723 241 251 5.50e-27 Steroid hormone receptor
ENSMODP00000020873 PRINTS PR00398 IPR001723 344 365 5.50e-27 Steroid hormone receptor
ENSMODP00000020873 PRINTS PR00398 IPR001723 365 381 5.50e-27 Steroid hormone receptor
ENSMODP00000020873 PRINTS PR00398 IPR001723 433 448 5.50e-27 Steroid hormone receptor
ENSMODP00000020873 PRINTS PR00398 IPR001723 501 518 5.50e-27 Steroid hormone receptor
ENSMODP00000020873 PRINTS PR00543 IPR001292 110 126 1.10e-77 Oestrogen receptor
ENSMODP00000020873 PRINTS PR00543 IPR001292 127 146 1.10e-77 Oestrogen receptor
ENSMODP00000020873 PRINTS PR00543 IPR001292 148 167 1.10e-77 Oestrogen receptor
ENSMODP00000020873 PRINTS PR00543 IPR001292 26 43 1.10e-77 Oestrogen receptor
ENSMODP00000020873 PRINTS PR00543 IPR001292 45 62 1.10e-77 Oestrogen receptor
ENSMODP00000020873 PRINTS PR00543 IPR001292 6 24 1.10e-77 Oestrogen receptor
ENSMODP00000020873 PRINTS PR00543 IPR001292 67 82 1.10e-77 Oestrogen receptor
ENSMODP00000020873 PRINTS PR00543 IPR001292 92 106 1.10e-77 Oestrogen receptor
ENSMODP00000020873 ProSitePatterns PS00031 IPR001628 180 206 - Zinc finger, nuclear hormone receptor-type
ENSMODP00000020873 ProSiteProfiles PS51030 IPR001628 177 252 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSMODP00000020873 SMART SM00399 IPR001628 177 248 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSMODP00000020873 SMART SM00430 IPR000536 343 513 3.30e-37 Nuclear hormone receptor, ligand-binding, core
ENSMODP00000020873 SUPERFAMILY SSF48508 IPR008946 230 256 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSMODP00000020873 SUPERFAMILY SSF48508 IPR008946 297 542 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMODP00000020873 PF02159 0 Oest_recep Oestrogen receptor
ENSMODP00000020873 PF00105 1.3e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSMODP00000020873 PF00104 5.9e-30 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSMODP00000020873 PF12743 8.1e-22 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMODP00000020873 GO:0006351 biological_process transcription, DNA-templated
ENSMODP00000020873 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSMODP00000020873 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSMODP00000020873 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSMODP00000020873 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSMODP00000020873 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSMODP00000020873 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSMODP00000020873 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSMODP00000020873 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSMODP00000020873 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSMODP00000020873 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSMODP00000020873 GO:0071392 biological_process cellular response to estradiol stimulus
ENSMODP00000020873 GO:0005634 cellular_component nucleus
ENSMODP00000020873 GO:0005794 cellular_component Golgi apparatus
ENSMODP00000020873 GO:0005886 cellular_component plasma membrane
ENSMODP00000020873 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSMODP00000020873 GO:0003707 molecular_function steroid hormone receptor activity
ENSMODP00000020873 GO:0005496 molecular_function steroid binding
ENSMODP00000020873 GO:0008270 molecular_function zinc ion binding
ENSMODP00000020873 GO:0030284 molecular_function estrogen receptor activity
ENSMODP00000020873 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus 100385918 9103 Meleagris gallopavo 100542782
61853 Nomascus leucogenys 100580202 10141 Cavia porcellus 100713276
10029 Cricetulus griseus 100768474 39432 Saimiri boliviensis 101034130
9669 Mustela putorius furo 101690352 8083 Xiphophorus maculatus 102235986
13735 Pelodiscus sinensis 102456765 10090 Mus musculus 13982
9606 Homo sapiens 2099 9646 Ailuropoda melanoleuca ENSAMEG00000011072
7955 Danio rerio ENSDARG00000004111 9371 Echinops telfairi ENSETEG00000006131
9685 Felis catus ENSFCAG00000031492 69293 Gasterosteus aculeatus ENSGACG00000008711
9031 Gallus gallus ENSGALG00000012973 30608 Microcebus murinus ENSMICG00000007592
59463 Myotis lucifugus ENSMLUG00000014181 30611 Otolemur garnettii ENSOGAG00000012580
8090 Oryzias latipes ENSORLG00000014514 10116 Rattus norvegicus ENSRNOG00000019358
42254 Sorex araneus ENSSARG00000004419 99883 Tetraodon nigroviridis ENSTNIG00000012264
31033 Takifugu rubripes ENSTRUG00000018219 9478 Tarsius syrichta ENSTSYG00000006280
9739 Tursiops truncatus ENSTTRG00000002996 8364 Xenopus tropicalis ENSXETG00000012364
9555 Papio anubis 100303417 9986 Oryctolagus cuniculus 100351261
9597 Pan paniscus 100980011 9615 Canis familiaris 403640
28377 Anolis carolinensis ENSACAG00000006213 9913 Bos taurus ENSBTAG00000007159
10020 Dipodomys ordii ENSDORG00000010443 9796 Equus caballus ENSECAG00000022441
9365 Erinaceus europaeus ENSEEUG00000000828 9595 Gorilla gorilla ENSGGOG00000009678
8049 Gadus morhua ENSGMOG00000014898 9315 Macropus eugenii ENSMEUG00000003564
9258 Ornithorhynchus anatinus ENSOANG00000015561 8128 Oreochromis niloticus ENSONIG00000013354
9978 Ochotona princeps ENSOPRG00000012663 132908 Pteropus vampyrus ENSPVAG00000001923
43179 Ictidomys tridecemlineatus ENSSTOG00000006748 37347 Tupaia belangeri ENSTBEG00000005946
59729 Taeniopygia guttata ENSTGUG00000011249 30538 Vicugna pacos ENSVPAG00000001185