Basic Information
Gene ID ENSMLUG00000014181
Gene Name ESR1
Full Name Estrogen receptor
Organism Myotis lucifugus [59463]

Cross Reference
UniProt G1PPH0 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMLUP00000012903 Gene3D G3DSA:1.10.565.10 IPR008946 195 225 2.80e-101 Nuclear hormone receptor, ligand-binding
ENSMLUP00000012903 Gene3D G3DSA:1.10.565.10 IPR008946 267 504 2.80e-101 Nuclear hormone receptor, ligand-binding
ENSMLUP00000012903 Gene3D G3DSA:3.30.50.10 IPR013088 141 194 8.70e-28 Zinc finger, NHR/GATA-type
ENSMLUP00000012903 Pfam PF00104 IPR000536 284 480 6.10e-29 Nuclear hormone receptor, ligand-binding, core
ENSMLUP00000012903 Pfam PF00105 IPR001628 140 208 2.00e-31 Zinc finger, nuclear hormone receptor-type
ENSMLUP00000012903 Pfam PF02159 IPR001292 5 137 3.40e-50 Oestrogen receptor
ENSMLUP00000012903 Pfam PF12743 IPR024736 508 551 4.20e-15 Oestrogen-type nuclear receptor final C-terminal domain
ENSMLUP00000012903 PIRSF PIRSF002527 IPR024178 1 546 6.00e-290 Oestrogen receptor/oestrogen-related receptor
ENSMLUP00000012903 PIRSF PIRSF500101 IPR001292 1 551 0.00e-00 Oestrogen receptor
ENSMLUP00000012903 PRINTS PR00047 IPR001628 141 157 6.20e-17 Zinc finger, nuclear hormone receptor-type
ENSMLUP00000012903 PRINTS PR00047 IPR001628 157 172 6.20e-17 Zinc finger, nuclear hormone receptor-type
ENSMLUP00000012903 PRINTS PR00047 IPR001628 190 198 6.20e-17 Zinc finger, nuclear hormone receptor-type
ENSMLUP00000012903 PRINTS PR00047 IPR001628 198 206 6.20e-17 Zinc finger, nuclear hormone receptor-type
ENSMLUP00000012903 PRINTS PR00398 IPR001723 202 212 1.20e-26 Steroid hormone receptor
ENSMLUP00000012903 PRINTS PR00398 IPR001723 305 326 1.20e-26 Steroid hormone receptor
ENSMLUP00000012903 PRINTS PR00398 IPR001723 326 342 1.20e-26 Steroid hormone receptor
ENSMLUP00000012903 PRINTS PR00398 IPR001723 394 409 1.20e-26 Steroid hormone receptor
ENSMLUP00000012903 PRINTS PR00398 IPR001723 462 479 1.20e-26 Steroid hormone receptor
ENSMLUP00000012903 PRINTS PR00543 IPR001292 109 128 6.20e-51 Oestrogen receptor
ENSMLUP00000012903 PRINTS PR00543 IPR001292 25 40 6.20e-51 Oestrogen receptor
ENSMLUP00000012903 PRINTS PR00543 IPR001292 53 67 6.20e-51 Oestrogen receptor
ENSMLUP00000012903 PRINTS PR00543 IPR001292 71 87 6.20e-51 Oestrogen receptor
ENSMLUP00000012903 PRINTS PR00543 IPR001292 88 107 6.20e-51 Oestrogen receptor
ENSMLUP00000012903 ProSitePatterns PS00031 IPR001628 141 167 - Zinc finger, nuclear hormone receptor-type
ENSMLUP00000012903 ProSiteProfiles PS51030 IPR001628 138 213 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSMLUP00000012903 SMART SM00399 IPR001628 138 209 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSMLUP00000012903 SMART SM00430 IPR000536 304 474 2.30e-37 Nuclear hormone receptor, ligand-binding, core
ENSMLUP00000012903 SUPERFAMILY SSF48508 IPR008946 191 217 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSMLUP00000012903 SUPERFAMILY SSF48508 IPR008946 258 503 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMLUP00000012903 PF02159 0 Oest_recep Oestrogen receptor
ENSMLUP00000012903 PF00105 1.2e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSMLUP00000012903 PF00104 4.2e-29 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSMLUP00000012903 PF12743 2.2e-15 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMLUP00000012903 GO:0006351 biological_process transcription, DNA-templated
ENSMLUP00000012903 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSMLUP00000012903 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSMLUP00000012903 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSMLUP00000012903 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSMLUP00000012903 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSMLUP00000012903 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSMLUP00000012903 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSMLUP00000012903 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSMLUP00000012903 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSMLUP00000012903 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSMLUP00000012903 GO:0071392 biological_process cellular response to estradiol stimulus
ENSMLUP00000012903 GO:0005634 cellular_component nucleus
ENSMLUP00000012903 GO:0005794 cellular_component Golgi apparatus
ENSMLUP00000012903 GO:0005886 cellular_component plasma membrane
ENSMLUP00000012903 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSMLUP00000012903 GO:0003707 molecular_function steroid hormone receptor activity
ENSMLUP00000012903 GO:0005496 molecular_function steroid binding
ENSMLUP00000012903 GO:0008270 molecular_function zinc ion binding
ENSMLUP00000012903 GO:0030284 molecular_function estrogen receptor activity
ENSMLUP00000012903 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 9103 Meleagris gallopavo 100542782
61853 Nomascus leucogenys 100580202 10029 Cricetulus griseus 100768474
9597 Pan paniscus 100980011 39432 Saimiri boliviensis 101034130
8083 Xiphophorus maculatus 102235986 13735 Pelodiscus sinensis 102456765
10090 Mus musculus 13982 9606 Homo sapiens 2099
9615 Canis familiaris 403640 28377 Anolis carolinensis ENSACAG00000006213
9913 Bos taurus ENSBTAG00000007159 7955 Danio rerio ENSDARG00000004111
10020 Dipodomys ordii ENSDORG00000010443 9796 Equus caballus ENSECAG00000022441
9365 Erinaceus europaeus ENSEEUG00000000828 9685 Felis catus ENSFCAG00000031492
69293 Gasterosteus aculeatus ENSGACG00000008711 9595 Gorilla gorilla ENSGGOG00000009678
8049 Gadus morhua ENSGMOG00000014898 9315 Macropus eugenii ENSMEUG00000003564
30608 Microcebus murinus ENSMICG00000007592 9483 Callithrix jacchus 100385918
10141 Cavia porcellus 100713276 9669 Mustela putorius furo 101690352
9646 Ailuropoda melanoleuca ENSAMEG00000011072 9371 Echinops telfairi ENSETEG00000006131
9031 Gallus gallus ENSGALG00000012973 8090 Oryzias latipes ENSORLG00000014514
31033 Takifugu rubripes ENSTRUG00000018219 9258 Ornithorhynchus anatinus ENSOANG00000015561
30611 Otolemur garnettii ENSOGAG00000012580 8128 Oreochromis niloticus ENSONIG00000013354
9978 Ochotona princeps ENSOPRG00000012663 132908 Pteropus vampyrus ENSPVAG00000001923
10116 Rattus norvegicus ENSRNOG00000019358 42254 Sorex araneus ENSSARG00000004419
43179 Ictidomys tridecemlineatus ENSSTOG00000006748 37347 Tupaia belangeri ENSTBEG00000005946
59729 Taeniopygia guttata ENSTGUG00000011249 99883 Tetraodon nigroviridis ENSTNIG00000012264
9478 Tarsius syrichta ENSTSYG00000006280 9739 Tursiops truncatus ENSTTRG00000002996
30538 Vicugna pacos ENSVPAG00000001185 8364 Xenopus tropicalis ENSXETG00000012364