Basic Information
Gene ID 2099 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name ESR1; ESR, NR3A1
Full Name Estrogen receptor
Organism Homo sapiens [9606]

Cross Reference
UniProt P03372 UniGene Hs.208124
PDB 4JDD OMIM 615363
KEGG hsa:2099 UCSC uc003qom.4

Protein Interactions
DIP DIP-5965N
IntAct P03372
MINT MINT-129047
STRING 9606.ENSP00000206249

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000405330 Gene3D G3DSA:1.10.565.10 IPR008946 239 269 3.40e-101 Nuclear hormone receptor, ligand-binding
ENSP00000405330 Gene3D G3DSA:1.10.565.10 IPR008946 311 548 3.40e-101 Nuclear hormone receptor, ligand-binding
ENSP00000405330 Gene3D G3DSA:3.30.50.10 IPR013088 185 238 9.60e-28 Zinc finger, NHR/GATA-type
ENSP00000405330 Pfam PF00104 IPR000536 327 524 2.40e-29 Nuclear hormone receptor, ligand-binding, core
ENSP00000405330 Pfam PF00105 IPR001628 184 252 2.20e-31 Zinc finger, nuclear hormone receptor-type
ENSP00000405330 Pfam PF02159 IPR001292 42 181 3.80e-51 Oestrogen receptor
ENSP00000405330 Pfam PF12743 IPR024736 552 595 8.10e-20 Oestrogen-type nuclear receptor final C-terminal domain
ENSP00000405330 PIRSF PIRSF002527 IPR024178 42 590 9.70e-294 Oestrogen receptor/oestrogen-related receptor
ENSP00000405330 PIRSF PIRSF500101 IPR001292 1 595 0.00e-00 Oestrogen receptor
ENSP00000405330 PRINTS PR00047 IPR001628 185 201 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSP00000405330 PRINTS PR00047 IPR001628 201 216 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSP00000405330 PRINTS PR00047 IPR001628 234 242 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSP00000405330 PRINTS PR00047 IPR001628 242 250 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSP00000405330 PRINTS PR00398 IPR001723 246 256 5.70e-27 Steroid hormone receptor
ENSP00000405330 PRINTS PR00398 IPR001723 349 370 5.70e-27 Steroid hormone receptor
ENSP00000405330 PRINTS PR00398 IPR001723 370 386 5.70e-27 Steroid hormone receptor
ENSP00000405330 PRINTS PR00398 IPR001723 438 453 5.70e-27 Steroid hormone receptor
ENSP00000405330 PRINTS PR00398 IPR001723 506 523 5.70e-27 Steroid hormone receptor
ENSP00000405330 PRINTS PR00543 IPR001292 115 131 5.00e-87 Oestrogen receptor
ENSP00000405330 PRINTS PR00543 IPR001292 132 151 5.00e-87 Oestrogen receptor
ENSP00000405330 PRINTS PR00543 IPR001292 153 172 5.00e-87 Oestrogen receptor
ENSP00000405330 PRINTS PR00543 IPR001292 26 43 5.00e-87 Oestrogen receptor
ENSP00000405330 PRINTS PR00543 IPR001292 45 62 5.00e-87 Oestrogen receptor
ENSP00000405330 PRINTS PR00543 IPR001292 6 24 5.00e-87 Oestrogen receptor
ENSP00000405330 PRINTS PR00543 IPR001292 70 85 5.00e-87 Oestrogen receptor
ENSP00000405330 PRINTS PR00543 IPR001292 97 111 5.00e-87 Oestrogen receptor
ENSP00000405330 ProSitePatterns PS00031 IPR001628 185 211 - Zinc finger, nuclear hormone receptor-type
ENSP00000405330 ProSiteProfiles PS51030 IPR001628 182 257 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSP00000405330 SMART SM00399 IPR001628 182 253 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSP00000405330 SMART SM00430 IPR000536 348 518 6.20e-38 Nuclear hormone receptor, ligand-binding, core
ENSP00000405330 SUPERFAMILY SSF48508 IPR008946 315 547 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000405330 PF02159 0 Oest_recep Oestrogen receptor
ENSP00000405330 PF00105 1.4e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSP00000405330 PF00104 1.6e-29 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSP00000405330 PF12743 4.3e-20 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000405330 GO:0006351 biological_process transcription, DNA-templated
ENSP00000405330 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000405330 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSP00000405330 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSP00000405330 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSP00000405330 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSP00000405330 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSP00000405330 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSP00000405330 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSP00000405330 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSP00000405330 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSP00000405330 GO:0071392 biological_process cellular response to estradiol stimulus
ENSP00000405330 GO:0005634 cellular_component nucleus
ENSP00000405330 GO:0005794 cellular_component Golgi apparatus
ENSP00000405330 GO:0005886 cellular_component plasma membrane
ENSP00000405330 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000405330 GO:0003707 molecular_function steroid hormone receptor activity
ENSP00000405330 GO:0005496 molecular_function steroid binding
ENSP00000405330 GO:0008270 molecular_function zinc ion binding
ENSP00000405330 GO:0030284 molecular_function estrogen receptor activity
ENSP00000405330 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 9601 Pongo abelii 100459579
9103 Meleagris gallopavo 100542782 61853 Nomascus leucogenys 100580202
10029 Cricetulus griseus 100768474 9597 Pan paniscus 100980011
39432 Saimiri boliviensis 101034130 8083 Xiphophorus maculatus 102235986
7897 Latimeria chalumnae 102366308 13735 Pelodiscus sinensis 102456765
10090 Mus musculus 13982 9483 Callithrix jacchus 100385918
10141 Cavia porcellus 100713276 9669 Mustela putorius furo 101690352
9544 Macaca mulatta 574110 9646 Ailuropoda melanoleuca ENSAMEG00000011072
9371 Echinops telfairi ENSETEG00000006131 9031 Gallus gallus ENSGALG00000012973
59463 Myotis lucifugus ENSMLUG00000014181 8090 Oryzias latipes ENSORLG00000014514
31033 Takifugu rubripes ENSTRUG00000018219 8364 Xenopus tropicalis ENSXETG00000012364
9615 Canis familiaris 403640 9598 Pan troglodytes 452964
28377 Anolis carolinensis ENSACAG00000006213 9913 Bos taurus ENSBTAG00000007159
9358 Choloepus hoffmanni ENSCHOG00000012987 7955 Danio rerio ENSDARG00000004111
9361 Dasypus novemcinctus ENSDNOG00000013868 10020 Dipodomys ordii ENSDORG00000010443
9796 Equus caballus ENSECAG00000022441 9365 Erinaceus europaeus ENSEEUG00000000828
9685 Felis catus ENSFCAG00000031492 69293 Gasterosteus aculeatus ENSGACG00000008711
9595 Gorilla gorilla ENSGGOG00000009678 8049 Gadus morhua ENSGMOG00000014898
9785 Loxodonta africana ENSLAFG00000017799 9315 Macropus eugenii ENSMEUG00000003564
30608 Microcebus murinus ENSMICG00000007592 9258 Ornithorhynchus anatinus ENSOANG00000015561
30611 Otolemur garnettii ENSOGAG00000012580 8128 Oreochromis niloticus ENSONIG00000013354
9978 Ochotona princeps ENSOPRG00000012663 9813 Procavia capensis ENSPCAG00000011157
7757 Petromyzon marinus ENSPMAG00000008530 132908 Pteropus vampyrus ENSPVAG00000001923
10116 Rattus norvegicus ENSRNOG00000019358 42254 Sorex araneus ENSSARG00000004419
9305 Sarcophilus harrisii ENSSHAG00000008174 9823 Sus scrofa ENSSSCG00000005109
43179 Ictidomys tridecemlineatus ENSSTOG00000006748 37347 Tupaia belangeri ENSTBEG00000005946
59729 Taeniopygia guttata ENSTGUG00000011249 99883 Tetraodon nigroviridis ENSTNIG00000012264
9478 Tarsius syrichta ENSTSYG00000006280 9739 Tursiops truncatus ENSTTRG00000002996
30538 Vicugna pacos ENSVPAG00000001185