Basic Information
Gene ID ENSXETG00000012364
Gene Name esr1
Full Name Estrogen receptor
Organism Xenopus tropicalis [8364]

Cross Reference
UniProt Q25C14 UniGene Str.8692
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSXETP00000027035 Gene3D G3DSA:1.10.565.10 IPR008946 233 263 1.50e-92 Nuclear hormone receptor, ligand-binding
ENSXETP00000027035 Gene3D G3DSA:1.10.565.10 IPR008946 302 539 1.50e-92 Nuclear hormone receptor, ligand-binding
ENSXETP00000027035 Gene3D G3DSA:3.30.50.10 IPR013088 179 232 1.00e-27 Zinc finger, NHR/GATA-type
ENSXETP00000027035 Pfam PF00104 IPR000536 320 515 4.30e-25 Nuclear hormone receptor, ligand-binding, core
ENSXETP00000027035 Pfam PF00105 IPR001628 178 246 2.70e-31 Zinc finger, nuclear hormone receptor-type
ENSXETP00000027035 Pfam PF02159 IPR001292 42 175 1.70e-52 Oestrogen receptor
ENSXETP00000027035 Pfam PF12743 IPR024736 543 585 2.90e-14 Oestrogen-type nuclear receptor final C-terminal domain
ENSXETP00000027035 PIRSF PIRSF002527 IPR024178 42 580 5.80e-299 Oestrogen receptor/oestrogen-related receptor
ENSXETP00000027035 PIRSF PIRSF500101 IPR001292 1 585 0.00e-00 Oestrogen receptor
ENSXETP00000027035 PRINTS PR00047 IPR001628 179 195 7.40e-17 Zinc finger, nuclear hormone receptor-type
ENSXETP00000027035 PRINTS PR00047 IPR001628 195 210 7.40e-17 Zinc finger, nuclear hormone receptor-type
ENSXETP00000027035 PRINTS PR00047 IPR001628 228 236 7.40e-17 Zinc finger, nuclear hormone receptor-type
ENSXETP00000027035 PRINTS PR00047 IPR001628 236 244 7.40e-17 Zinc finger, nuclear hormone receptor-type
ENSXETP00000027035 PRINTS PR00398 IPR001723 240 250 2.60e-26 Steroid hormone receptor
ENSXETP00000027035 PRINTS PR00398 IPR001723 340 361 2.60e-26 Steroid hormone receptor
ENSXETP00000027035 PRINTS PR00398 IPR001723 361 377 2.60e-26 Steroid hormone receptor
ENSXETP00000027035 PRINTS PR00398 IPR001723 429 444 2.60e-26 Steroid hormone receptor
ENSXETP00000027035 PRINTS PR00398 IPR001723 497 514 2.60e-26 Steroid hormone receptor
ENSXETP00000027035 PRINTS PR00543 IPR001292 109 125 1.10e-72 Oestrogen receptor
ENSXETP00000027035 PRINTS PR00543 IPR001292 126 145 1.10e-72 Oestrogen receptor
ENSXETP00000027035 PRINTS PR00543 IPR001292 147 166 1.10e-72 Oestrogen receptor
ENSXETP00000027035 PRINTS PR00543 IPR001292 26 43 1.10e-72 Oestrogen receptor
ENSXETP00000027035 PRINTS PR00543 IPR001292 45 62 1.10e-72 Oestrogen receptor
ENSXETP00000027035 PRINTS PR00543 IPR001292 6 24 1.10e-72 Oestrogen receptor
ENSXETP00000027035 PRINTS PR00543 IPR001292 67 82 1.10e-72 Oestrogen receptor
ENSXETP00000027035 PRINTS PR00543 IPR001292 92 106 1.10e-72 Oestrogen receptor
ENSXETP00000027035 ProSitePatterns PS00031 IPR001628 179 205 - Zinc finger, nuclear hormone receptor-type
ENSXETP00000027035 ProSiteProfiles PS51030 IPR001628 176 251 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSXETP00000027035 SMART SM00399 IPR001628 176 247 3.40e-40 Zinc finger, nuclear hormone receptor-type
ENSXETP00000027035 SMART SM00430 IPR000536 339 509 7.30e-31 Nuclear hormone receptor, ligand-binding, core
ENSXETP00000027035 SUPERFAMILY SSF48508 IPR008946 306 538 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSXETP00000027035 PF02159 0 Oest_recep Oestrogen receptor
ENSXETP00000027035 PF00105 1.6e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSXETP00000027035 PF00104 2.7e-25 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSXETP00000027035 PF12743 2.9e-14 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSXETP00000027035 GO:0006351 biological_process transcription, DNA-templated
ENSXETP00000027035 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSXETP00000027035 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSXETP00000027035 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSXETP00000027035 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSXETP00000027035 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSXETP00000027035 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSXETP00000027035 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSXETP00000027035 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSXETP00000027035 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSXETP00000027035 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSXETP00000027035 GO:0071392 biological_process cellular response to estradiol stimulus
ENSXETP00000027035 GO:0005634 cellular_component nucleus
ENSXETP00000027035 GO:0005794 cellular_component Golgi apparatus
ENSXETP00000027035 GO:0005886 cellular_component plasma membrane
ENSXETP00000027035 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSXETP00000027035 GO:0003707 molecular_function steroid hormone receptor activity
ENSXETP00000027035 GO:0005496 molecular_function steroid binding
ENSXETP00000027035 GO:0008270 molecular_function zinc ion binding
ENSXETP00000027035 GO:0030284 molecular_function estrogen receptor activity
ENSXETP00000027035 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 9103 Meleagris gallopavo 100542782
61853 Nomascus leucogenys 100580202 10029 Cricetulus griseus 100768474
9597 Pan paniscus 100980011 39432 Saimiri boliviensis 101034130
8083 Xiphophorus maculatus 102235986 13735 Pelodiscus sinensis 102456765
10090 Mus musculus 13982 9606 Homo sapiens 2099
9615 Canis familiaris 403640 28377 Anolis carolinensis ENSACAG00000006213
9913 Bos taurus ENSBTAG00000007159 7955 Danio rerio ENSDARG00000004111
10020 Dipodomys ordii ENSDORG00000010443 9796 Equus caballus ENSECAG00000022441
9685 Felis catus ENSFCAG00000031492 69293 Gasterosteus aculeatus ENSGACG00000008711
9595 Gorilla gorilla ENSGGOG00000009678 8049 Gadus morhua ENSGMOG00000014898
9315 Macropus eugenii ENSMEUG00000003564 30608 Microcebus murinus ENSMICG00000007592
9258 Ornithorhynchus anatinus ENSOANG00000015561 30611 Otolemur garnettii ENSOGAG00000012580
8128 Oreochromis niloticus ENSONIG00000013354 9978 Ochotona princeps ENSOPRG00000012663
132908 Pteropus vampyrus ENSPVAG00000001923 10116 Rattus norvegicus ENSRNOG00000019358
42254 Sorex araneus ENSSARG00000004419 43179 Ictidomys tridecemlineatus ENSSTOG00000006748
37347 Tupaia belangeri ENSTBEG00000005946 59729 Taeniopygia guttata ENSTGUG00000011249
99883 Tetraodon nigroviridis ENSTNIG00000012264 9478 Tarsius syrichta ENSTSYG00000006280
9739 Tursiops truncatus ENSTTRG00000002996 30538 Vicugna pacos ENSVPAG00000001185
9483 Callithrix jacchus 100385918 10141 Cavia porcellus 100713276
9669 Mustela putorius furo 101690352 9646 Ailuropoda melanoleuca ENSAMEG00000011072
9371 Echinops telfairi ENSETEG00000006131 9031 Gallus gallus ENSGALG00000012973
59463 Myotis lucifugus ENSMLUG00000014181 8090 Oryzias latipes ENSORLG00000014514
31033 Takifugu rubripes ENSTRUG00000018219