Basic Information
Gene ID 403640
Gene Name ESR1
Full Name Estrogen receptor
Organism Canis familiaris [9615]

Cross Reference
UniProt F6V0I8 UniGene Cfa.3504
PDB NULL OMIM NULL
KEGG cfa:403640 UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSCAFP00000000624 Gene3D G3DSA:1.10.565.10 IPR008946 240 270 1.80e-101 Nuclear hormone receptor, ligand-binding
ENSCAFP00000000624 Gene3D G3DSA:1.10.565.10 IPR008946 312 549 1.80e-101 Nuclear hormone receptor, ligand-binding
ENSCAFP00000000624 Gene3D G3DSA:3.30.50.10 IPR013088 186 239 9.70e-28 Zinc finger, NHR/GATA-type
ENSCAFP00000000624 Pfam PF00104 IPR000536 332 525 6.70e-29 Nuclear hormone receptor, ligand-binding, core
ENSCAFP00000000624 Pfam PF00105 IPR001628 185 253 2.20e-31 Zinc finger, nuclear hormone receptor-type
ENSCAFP00000000624 Pfam PF02159 IPR001292 40 182 5.30e-47 Oestrogen receptor
ENSCAFP00000000624 Pfam PF12743 IPR024736 553 596 3.00e-21 Oestrogen-type nuclear receptor final C-terminal domain
ENSCAFP00000000624 PIRSF PIRSF002527 IPR024178 40 591 2.10e-295 Oestrogen receptor/oestrogen-related receptor
ENSCAFP00000000624 PIRSF PIRSF500101 IPR001292 1 596 0.00e-00 Oestrogen receptor
ENSCAFP00000000624 PRINTS PR00047 IPR001628 186 202 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSCAFP00000000624 PRINTS PR00047 IPR001628 202 217 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSCAFP00000000624 PRINTS PR00047 IPR001628 235 243 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSCAFP00000000624 PRINTS PR00047 IPR001628 243 251 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSCAFP00000000624 PRINTS PR00398 IPR001723 247 257 5.50e-27 Steroid hormone receptor
ENSCAFP00000000624 PRINTS PR00398 IPR001723 350 371 5.50e-27 Steroid hormone receptor
ENSCAFP00000000624 PRINTS PR00398 IPR001723 371 387 5.50e-27 Steroid hormone receptor
ENSCAFP00000000624 PRINTS PR00398 IPR001723 439 454 5.50e-27 Steroid hormone receptor
ENSCAFP00000000624 PRINTS PR00398 IPR001723 507 524 5.50e-27 Steroid hormone receptor
ENSCAFP00000000624 PRINTS PR00543 IPR001292 116 132 2.30e-72 Oestrogen receptor
ENSCAFP00000000624 PRINTS PR00543 IPR001292 133 152 2.30e-72 Oestrogen receptor
ENSCAFP00000000624 PRINTS PR00543 IPR001292 154 173 2.30e-72 Oestrogen receptor
ENSCAFP00000000624 PRINTS PR00543 IPR001292 24 41 2.30e-72 Oestrogen receptor
ENSCAFP00000000624 PRINTS PR00543 IPR001292 4 22 2.30e-72 Oestrogen receptor
ENSCAFP00000000624 PRINTS PR00543 IPR001292 43 60 2.30e-72 Oestrogen receptor
ENSCAFP00000000624 PRINTS PR00543 IPR001292 68 83 2.30e-72 Oestrogen receptor
ENSCAFP00000000624 ProSitePatterns PS00031 IPR001628 186 212 - Zinc finger, nuclear hormone receptor-type
ENSCAFP00000000624 ProSiteProfiles PS51030 IPR001628 183 258 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSCAFP00000000624 SMART SM00399 IPR001628 183 254 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSCAFP00000000624 SMART SM00430 IPR000536 349 519 9.60e-38 Nuclear hormone receptor, ligand-binding, core
ENSCAFP00000000624 SUPERFAMILY SSF48508 IPR008946 236 262 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSCAFP00000000624 SUPERFAMILY SSF48508 IPR008946 303 548 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSCAFP00000000624 PF02159 0 Oest_recep Oestrogen receptor
ENSCAFP00000000624 PF00105 1.4e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSCAFP00000000624 PF00104 4.2e-29 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSCAFP00000000624 PF12743 1.5e-21 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSCAFP00000000624 GO:0006351 biological_process transcription, DNA-templated
ENSCAFP00000000624 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSCAFP00000000624 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSCAFP00000000624 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSCAFP00000000624 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSCAFP00000000624 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSCAFP00000000624 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSCAFP00000000624 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSCAFP00000000624 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSCAFP00000000624 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSCAFP00000000624 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSCAFP00000000624 GO:0071392 biological_process cellular response to estradiol stimulus
ENSCAFP00000000624 GO:0005634 cellular_component nucleus
ENSCAFP00000000624 GO:0005794 cellular_component Golgi apparatus
ENSCAFP00000000624 GO:0005886 cellular_component plasma membrane
ENSCAFP00000000624 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSCAFP00000000624 GO:0003707 molecular_function steroid hormone receptor activity
ENSCAFP00000000624 GO:0005496 molecular_function steroid binding
ENSCAFP00000000624 GO:0008270 molecular_function zinc ion binding
ENSCAFP00000000624 GO:0030284 molecular_function estrogen receptor activity
ENSCAFP00000000624 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 9483 Callithrix jacchus 100385918
9103 Meleagris gallopavo 100542782 61853 Nomascus leucogenys 100580202
10141 Cavia porcellus 100713276 10029 Cricetulus griseus 100768474
9597 Pan paniscus 100980011 39432 Saimiri boliviensis 101034130
9669 Mustela putorius furo 101690352 8083 Xiphophorus maculatus 102235986
13735 Pelodiscus sinensis 102456765 10090 Mus musculus 13982
9606 Homo sapiens 2099 28377 Anolis carolinensis ENSACAG00000006213
9646 Ailuropoda melanoleuca ENSAMEG00000011072 9913 Bos taurus ENSBTAG00000007159
7955 Danio rerio ENSDARG00000004111 9365 Erinaceus europaeus ENSEEUG00000000828
9371 Echinops telfairi ENSETEG00000006131 9685 Felis catus ENSFCAG00000031492
69293 Gasterosteus aculeatus ENSGACG00000008711 9031 Gallus gallus ENSGALG00000012973
30608 Microcebus murinus ENSMICG00000007592 59463 Myotis lucifugus ENSMLUG00000014181
9258 Ornithorhynchus anatinus ENSOANG00000015561 30611 Otolemur garnettii ENSOGAG00000012580
8128 Oreochromis niloticus ENSONIG00000013354 9978 Ochotona princeps ENSOPRG00000012663
8090 Oryzias latipes ENSORLG00000014514 10116 Rattus norvegicus ENSRNOG00000019358
42254 Sorex araneus ENSSARG00000004419 99883 Tetraodon nigroviridis ENSTNIG00000012264
31033 Takifugu rubripes ENSTRUG00000018219 9478 Tarsius syrichta ENSTSYG00000006280
9739 Tursiops truncatus ENSTTRG00000002996 8364 Xenopus tropicalis ENSXETG00000012364
10020 Dipodomys ordii ENSDORG00000010443 9796 Equus caballus ENSECAG00000022441
9595 Gorilla gorilla ENSGGOG00000009678 8049 Gadus morhua ENSGMOG00000014898
9315 Macropus eugenii ENSMEUG00000003564 132908 Pteropus vampyrus ENSPVAG00000001923
43179 Ictidomys tridecemlineatus ENSSTOG00000006748 37347 Tupaia belangeri ENSTBEG00000005946
59729 Taeniopygia guttata ENSTGUG00000011249 30538 Vicugna pacos ENSVPAG00000001185