Basic Information
Gene ID 24842 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Tp53; P53
Full Name Cellular tumor antigen p53
Organism Rattus norvegicus [10116]

Cross Reference
UniProt P10361 UniGene Rn.54443
PDB NULL OMIM NULL
KEGG rno:24842 UCSC RGD:3889

Protein Interactions
DIP DIP-46016N
IntAct P10361
MINT MINT-4651801
STRING 10116.ENSRNOP00000047840

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSRNOP00000047840 Gene3D G3DSA:2.60.40.720 IPR012346 92 293 1.30e-95 p53/RUNT-type transcription factor, DNA-binding domain
ENSRNOP00000047840 Gene3D G3DSA:4.10.170.10 IPR010991 317 356 1.10e-19 p53, tetramerisation domain
ENSRNOP00000047840 PANTHER PTHR11447 IPR002117 1 391 0.00e-00 p53 tumour suppressor family
ENSRNOP00000047840 Pfam PF00870 IPR011615 93 286 1.20e-105 p53, DNA-binding domain
ENSRNOP00000047840 Pfam PF07710 IPR010991 317 356 1.30e-18 p53, tetramerisation domain
ENSRNOP00000047840 Pfam PF08563 IPR013872 6 27 1.50e-07 p53 transactivation domain
ENSRNOP00000047840 PRINTS PR00386 IPR002117 114 140 1.30e-86 p53 tumour suppressor family
ENSRNOP00000047840 PRINTS PR00386 IPR002117 156 177 1.30e-86 p53 tumour suppressor family
ENSRNOP00000047840 PRINTS PR00386 IPR002117 211 232 1.30e-86 p53 tumour suppressor family
ENSRNOP00000047840 PRINTS PR00386 IPR002117 234 256 1.30e-86 p53 tumour suppressor family
ENSRNOP00000047840 PRINTS PR00386 IPR002117 262 284 1.30e-86 p53 tumour suppressor family
ENSRNOP00000047840 PRINTS PR00386 IPR002117 324 348 1.30e-86 p53 tumour suppressor family
ENSRNOP00000047840 ProSitePatterns PS00348 IPR002117 235 247 - p53 tumour suppressor family
ENSRNOP00000047840 SUPERFAMILY SSF47719 IPR010991 317 352 0.00e-00 p53, tetramerisation domain
ENSRNOP00000047840 SUPERFAMILY SSF49417 IPR008967 95 285 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSRNOP00000047840 PF00870 0 P53 P53 DNA-binding domain
ENSRNOP00000047840 PF07710 6.4e-19 P53_tetramer P53 tetramerisation motif
ENSRNOP00000047840 PF08563 5.5e-08 P53_TAD P53 transactivation motif

Gene Ontology Annotation
Protein Entry Name Space Description
ENSRNOP00000047840 GO:0000733 biological_process DNA strand renaturation
ENSRNOP00000047840 GO:0006289 biological_process nucleotide-excision repair
ENSRNOP00000047840 GO:0006351 biological_process transcription, DNA-templated
ENSRNOP00000047840 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSRNOP00000047840 GO:0006915 biological_process apoptotic process
ENSRNOP00000047840 GO:0007049 biological_process cell cycle
ENSRNOP00000047840 GO:0007275 biological_process multicellular organismal development
ENSRNOP00000047840 GO:0007569 biological_process cell aging
ENSRNOP00000047840 GO:0012501 biological_process programmed cell death
ENSRNOP00000047840 GO:0030308 biological_process negative regulation of cell growth
ENSRNOP00000047840 GO:0051262 biological_process protein tetramerization
ENSRNOP00000047840 GO:0090200 biological_process positive regulation of release of cytochrome c from mitochondria
ENSRNOP00000047840 GO:0097252 biological_process oligodendrocyte apoptotic process
ENSRNOP00000047840 GO:0005634 cellular_component nucleus
ENSRNOP00000047840 GO:0005730 cellular_component nucleolus
ENSRNOP00000047840 GO:0005737 cellular_component cytoplasm
ENSRNOP00000047840 GO:0005739 cellular_component mitochondrion
ENSRNOP00000047840 GO:0005759 cellular_component mitochondrial matrix
ENSRNOP00000047840 GO:0005783 cellular_component endoplasmic reticulum
ENSRNOP00000047840 GO:0003677 molecular_function DNA binding
ENSRNOP00000047840 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSRNOP00000047840 GO:0005507 molecular_function copper ion binding
ENSRNOP00000047840 GO:0005524 molecular_function ATP binding
ENSRNOP00000047840 GO:0044212 molecular_function transcription regulatory region DNA binding
ENSRNOP00000047840 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7425 Nasonia vitripennis 100116126 30195 Bombus terrestris 100648488
10029 Cricetulus griseus 100682525 8128 Oreochromis niloticus 100702587
132113 Bombus impatiens 100748472 7463 Apis florea 100862994
9305 Sarcophilus harrisii 100922473 9597 Pan paniscus 100973941
39432 Saimiri boliviensis 101043647 43179 Ictidomys tridecemlineatus 101957738
8083 Xiphophorus maculatus 102219062 7029 Acyrthosiphon pisum 100160742
10224 Saccoglossus kowalevskii 100313697 10141 Cavia porcellus 100379269
9483 Callithrix jacchus 100415710 9601 Pongo abelii 100435218
7460 Apis mellifera 100577122 143995 Megachile rotundata 100880552
9555 Papio anubis 101006608 9595 Gorilla gorilla 101133524
6087 Hydra magnipapillata 101235318 13735 Pelodiscus sinensis 102448135
9598 Pan troglodytes 455214 9685 Felis catus 493847
9606 Homo sapiens 7157 28377 Anolis carolinensis ENSACAG00000001622
9358 Choloepus hoffmanni ENSCHOG00000010497 9365 Erinaceus europaeus ENSEEUG00000014573
8049 Gadus morhua ENSGMOG00000000413 9315 Macropus eugenii ENSMEUG00000013135
9103 Meleagris gallopavo ENSMGAG00000001562 59463 Myotis lucifugus ENSMLUG00000006411
9544 Macaca mulatta ENSMMUG00000016569 9669 Mustela putorius furo ENSMPUG00000009017
9258 Ornithorhynchus anatinus ENSOANG00000013795 9813 Procavia capensis ENSPCAG00000012725
7757 Petromyzon marinus ENSPMAG00000009535 132908 Pteropus vampyrus ENSPVAG00000016317
9478 Tarsius syrichta ENSTSYG00000003709 30538 Vicugna pacos ENSVPAG00000012350
8364 Xenopus tropicalis ENSXETG00000025055 7955 Danio rerio 368221
7668 Strongylocentrotus purpuratus 756859 9646 Ailuropoda melanoleuca ENSAMEG00000000763
9615 Canis familiaris ENSCAFG00000016714 7719 Ciona intestinalis ENSCING00000002175
51511 Ciona savignyi ENSCSAVG00000009964 9361 Dasypus novemcinctus ENSDNOG00000005252
10020 Dipodomys ordii ENSDORG00000002061 9796 Equus caballus ENSECAG00000008126
9371 Echinops telfairi ENSETEG00000008987 69293 Gasterosteus aculeatus ENSGACG00000013629
9031 Gallus gallus ENSGALG00000007324 7897 Latimeria chalumnae ENSLACG00000014014
9785 Loxodonta africana ENSLAFG00000007483 30608 Microcebus murinus ENSMICG00000014853
13616 Monodelphis domestica ENSMODG00000015060 61853 Nomascus leucogenys ENSNLEG00000009730
9986 Oryctolagus cuniculus ENSOCUG00000001138 30611 Otolemur garnettii ENSOGAG00000016871
9978 Ochotona princeps ENSOPRG00000006441 8090 Oryzias latipes ENSORLG00000015665
42254 Sorex araneus ENSSARG00000006206 9823 Sus scrofa ENSSSCG00000025592
37347 Tupaia belangeri ENSTBEG00000011771 59729 Taeniopygia guttata ENSTGUG00000009377
99883 Tetraodon nigroviridis ENSTNIG00000010137 31033 Takifugu rubripes ENSTRUG00000003420
9739 Tursiops truncatus ENSTTRG00000010250

Paralogs
ENSRNOG00000046657 ENSRNOG00000013775