Basic Information
Gene ID 7157 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name TP53; P53
Full Name Cellular tumor antigen p53
Organism Homo sapiens [9606]

Cross Reference
UniProt P04637 UniGene Hs.740601
PDB 4MZR OMIM 614740
KEGG hsa:7157 UCSC uc010cni.2

Protein Interactions
DIP DIP-368N
IntAct P04637
MINT MINT-91013
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
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REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000269305 Gene3D G3DSA:2.60.40.720 IPR012346 94 297 3.20e-97 p53/RUNT-type transcription factor, DNA-binding domain
ENSP00000269305 Gene3D G3DSA:4.10.170.10 IPR010991 319 359 1.70e-21 p53, tetramerisation domain
ENSP00000269305 PANTHER PTHR11447 IPR002117 1 393 0.00e-00 p53 tumour suppressor family
ENSP00000269305 Pfam PF00870 IPR011615 95 288 1.20e-109 p53, DNA-binding domain
ENSP00000269305 Pfam PF07710 IPR010991 318 358 1.00e-19 p53, tetramerisation domain
ENSP00000269305 Pfam PF08563 IPR013872 6 29 2.20e-10 p53 transactivation domain
ENSP00000269305 PRINTS PR00386 IPR002117 116 142 6.00e-87 p53 tumour suppressor family
ENSP00000269305 PRINTS PR00386 IPR002117 158 179 6.00e-87 p53 tumour suppressor family
ENSP00000269305 PRINTS PR00386 IPR002117 213 234 6.00e-87 p53 tumour suppressor family
ENSP00000269305 PRINTS PR00386 IPR002117 236 258 6.00e-87 p53 tumour suppressor family
ENSP00000269305 PRINTS PR00386 IPR002117 264 286 6.00e-87 p53 tumour suppressor family
ENSP00000269305 PRINTS PR00386 IPR002117 326 350 6.00e-87 p53 tumour suppressor family
ENSP00000269305 ProSitePatterns PS00348 IPR002117 237 249 - p53 tumour suppressor family
ENSP00000269305 SUPERFAMILY SSF47719 IPR010991 319 357 0.00e-00 p53, tetramerisation domain
ENSP00000269305 SUPERFAMILY SSF49417 IPR008967 97 287 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000269305 PF00870 0 P53 P53 DNA-binding domain
ENSP00000269305 PF07710 5.5e-20 P53_tetramer P53 tetramerisation motif
ENSP00000269305 PF08563 1e-10 P53_TAD P53 transactivation motif

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000269305 GO:0000733 biological_process DNA strand renaturation
ENSP00000269305 GO:0006289 biological_process nucleotide-excision repair
ENSP00000269305 GO:0006351 biological_process transcription, DNA-templated
ENSP00000269305 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000269305 GO:0006915 biological_process apoptotic process
ENSP00000269305 GO:0007049 biological_process cell cycle
ENSP00000269305 GO:0007275 biological_process multicellular organismal development
ENSP00000269305 GO:0007569 biological_process cell aging
ENSP00000269305 GO:0012501 biological_process programmed cell death
ENSP00000269305 GO:0030308 biological_process negative regulation of cell growth
ENSP00000269305 GO:0051262 biological_process protein tetramerization
ENSP00000269305 GO:0090200 biological_process positive regulation of release of cytochrome c from mitochondria
ENSP00000269305 GO:0097252 biological_process oligodendrocyte apoptotic process
ENSP00000269305 GO:0005634 cellular_component nucleus
ENSP00000269305 GO:0005730 cellular_component nucleolus
ENSP00000269305 GO:0005737 cellular_component cytoplasm
ENSP00000269305 GO:0005739 cellular_component mitochondrion
ENSP00000269305 GO:0005759 cellular_component mitochondrial matrix
ENSP00000269305 GO:0005783 cellular_component endoplasmic reticulum
ENSP00000269305 GO:0003677 molecular_function DNA binding
ENSP00000269305 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000269305 GO:0005507 molecular_function copper ion binding
ENSP00000269305 GO:0005524 molecular_function ATP binding
ENSP00000269305 GO:0044212 molecular_function transcription regulatory region DNA binding
ENSP00000269305 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10029 Cricetulus griseus 100682525 8128 Oreochromis niloticus 100702587
9305 Sarcophilus harrisii 100922473 9597 Pan paniscus 100973941
39432 Saimiri boliviensis 101043647 43179 Ictidomys tridecemlineatus 101957738
8083 Xiphophorus maculatus 102219062 10116 Rattus norvegicus 24842
10141 Cavia porcellus 100379269 9483 Callithrix jacchus 100415710
9601 Pongo abelii 100435218 9555 Papio anubis 101006608
9595 Gorilla gorilla 101133524 13735 Pelodiscus sinensis 102448135
9598 Pan troglodytes 455214 9685 Felis catus 493847
9365 Erinaceus europaeus ENSEEUG00000014573 9315 Macropus eugenii ENSMEUG00000013135
59463 Myotis lucifugus ENSMLUG00000006411 9669 Mustela putorius furo ENSMPUG00000009017
9813 Procavia capensis ENSPCAG00000012725 132908 Pteropus vampyrus ENSPVAG00000016317
8364 Xenopus tropicalis ENSXETG00000025055 9615 Canis familiaris ENSCAFG00000016714
9361 Dasypus novemcinctus ENSDNOG00000005252 9796 Equus caballus ENSECAG00000008126
9371 Echinops telfairi ENSETEG00000008987 7897 Latimeria chalumnae ENSLACG00000014014
9785 Loxodonta africana ENSLAFG00000007483 30608 Microcebus murinus ENSMICG00000014853
61853 Nomascus leucogenys ENSNLEG00000009730 9986 Oryctolagus cuniculus ENSOCUG00000001138
30611 Otolemur garnettii ENSOGAG00000016871 9978 Ochotona princeps ENSOPRG00000006441
42254 Sorex araneus ENSSARG00000006206 37347 Tupaia belangeri ENSTBEG00000011771
9739 Tursiops truncatus ENSTTRG00000010250