Basic Information | |||
Gene ID | 7157 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | TP53; P53 | ||
Full Name | Cellular tumor antigen p53 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | P04637 | UniGene | Hs.740601 |
PDB | 4MZR | OMIM | 614740 |
KEGG | hsa:7157 | UCSC | uc010cni.2 |
Protein Interactions | |
DIP | DIP-368N |
IntAct | P04637 |
MINT | MINT-91013 |
STRING | NULL |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
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REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000269305 | Gene3D | G3DSA:2.60.40.720 | IPR012346 | 94 | 297 | 3.20e-97 | p53/RUNT-type transcription factor, DNA-binding domain |
ENSP00000269305 | Gene3D | G3DSA:4.10.170.10 | IPR010991 | 319 | 359 | 1.70e-21 | p53, tetramerisation domain |
ENSP00000269305 | PANTHER | PTHR11447 | IPR002117 | 1 | 393 | 0.00e-00 | p53 tumour suppressor family |
ENSP00000269305 | Pfam | PF00870 | IPR011615 | 95 | 288 | 1.20e-109 | p53, DNA-binding domain |
ENSP00000269305 | Pfam | PF07710 | IPR010991 | 318 | 358 | 1.00e-19 | p53, tetramerisation domain |
ENSP00000269305 | Pfam | PF08563 | IPR013872 | 6 | 29 | 2.20e-10 | p53 transactivation domain |
ENSP00000269305 | PRINTS | PR00386 | IPR002117 | 116 | 142 | 6.00e-87 | p53 tumour suppressor family |
ENSP00000269305 | PRINTS | PR00386 | IPR002117 | 158 | 179 | 6.00e-87 | p53 tumour suppressor family |
ENSP00000269305 | PRINTS | PR00386 | IPR002117 | 213 | 234 | 6.00e-87 | p53 tumour suppressor family |
ENSP00000269305 | PRINTS | PR00386 | IPR002117 | 236 | 258 | 6.00e-87 | p53 tumour suppressor family |
ENSP00000269305 | PRINTS | PR00386 | IPR002117 | 264 | 286 | 6.00e-87 | p53 tumour suppressor family |
ENSP00000269305 | PRINTS | PR00386 | IPR002117 | 326 | 350 | 6.00e-87 | p53 tumour suppressor family |
ENSP00000269305 | ProSitePatterns | PS00348 | IPR002117 | 237 | 249 | - | p53 tumour suppressor family |
ENSP00000269305 | SUPERFAMILY | SSF47719 | IPR010991 | 319 | 357 | 0.00e-00 | p53, tetramerisation domain |
ENSP00000269305 | SUPERFAMILY | SSF49417 | IPR008967 | 97 | 287 | 0.00e-00 | p53-like transcription factor, DNA-binding |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000269305 | PF00870 | 0 | P53 | P53 DNA-binding domain |
ENSP00000269305 | PF07710 | 5.5e-20 | P53_tetramer | P53 tetramerisation motif |
ENSP00000269305 | PF08563 | 1e-10 | P53_TAD | P53 transactivation motif |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000269305 | GO:0000733 | biological_process | DNA strand renaturation |
ENSP00000269305 | GO:0006289 | biological_process | nucleotide-excision repair |
ENSP00000269305 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000269305 | GO:0006355 | biological_process | regulation of transcription, DNA-templated |
ENSP00000269305 | GO:0006915 | biological_process | apoptotic process |
ENSP00000269305 | GO:0007049 | biological_process | cell cycle |
ENSP00000269305 | GO:0007275 | biological_process | multicellular organismal development |
ENSP00000269305 | GO:0007569 | biological_process | cell aging |
ENSP00000269305 | GO:0012501 | biological_process | programmed cell death |
ENSP00000269305 | GO:0030308 | biological_process | negative regulation of cell growth |
ENSP00000269305 | GO:0051262 | biological_process | protein tetramerization |
ENSP00000269305 | GO:0090200 | biological_process | positive regulation of release of cytochrome c from mitochondria |
ENSP00000269305 | GO:0097252 | biological_process | oligodendrocyte apoptotic process |
ENSP00000269305 | GO:0005634 | cellular_component | nucleus |
ENSP00000269305 | GO:0005730 | cellular_component | nucleolus |
ENSP00000269305 | GO:0005737 | cellular_component | cytoplasm |
ENSP00000269305 | GO:0005739 | cellular_component | mitochondrion |
ENSP00000269305 | GO:0005759 | cellular_component | mitochondrial matrix |
ENSP00000269305 | GO:0005783 | cellular_component | endoplasmic reticulum |
ENSP00000269305 | GO:0003677 | molecular_function | DNA binding |
ENSP00000269305 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSP00000269305 | GO:0005507 | molecular_function | copper ion binding |
ENSP00000269305 | GO:0005524 | molecular_function | ATP binding |
ENSP00000269305 | GO:0044212 | molecular_function | transcription regulatory region DNA binding |
ENSP00000269305 | GO:0046872 | molecular_function | metal ion binding |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
10029 | Cricetulus griseus | 100682525 | 8128 | Oreochromis niloticus | 100702587 |
9305 | Sarcophilus harrisii | 100922473 | 9597 | Pan paniscus | 100973941 |
39432 | Saimiri boliviensis | 101043647 | 43179 | Ictidomys tridecemlineatus | 101957738 |
8083 | Xiphophorus maculatus | 102219062 | 10116 | Rattus norvegicus | 24842 |
10141 | Cavia porcellus | 100379269 | 9483 | Callithrix jacchus | 100415710 |
9601 | Pongo abelii | 100435218 | 9555 | Papio anubis | 101006608 |
9595 | Gorilla gorilla | 101133524 | 13735 | Pelodiscus sinensis | 102448135 |
9598 | Pan troglodytes | 455214 | 9685 | Felis catus | 493847 |
9365 | Erinaceus europaeus | ENSEEUG00000014573 | 9315 | Macropus eugenii | ENSMEUG00000013135 |
59463 | Myotis lucifugus | ENSMLUG00000006411 | 9669 | Mustela putorius furo | ENSMPUG00000009017 |
9813 | Procavia capensis | ENSPCAG00000012725 | 132908 | Pteropus vampyrus | ENSPVAG00000016317 |
8364 | Xenopus tropicalis | ENSXETG00000025055 | 9615 | Canis familiaris | ENSCAFG00000016714 |
9361 | Dasypus novemcinctus | ENSDNOG00000005252 | 9796 | Equus caballus | ENSECAG00000008126 |
9371 | Echinops telfairi | ENSETEG00000008987 | 7897 | Latimeria chalumnae | ENSLACG00000014014 |
9785 | Loxodonta africana | ENSLAFG00000007483 | 30608 | Microcebus murinus | ENSMICG00000014853 |
61853 | Nomascus leucogenys | ENSNLEG00000009730 | 9986 | Oryctolagus cuniculus | ENSOCUG00000001138 |
30611 | Otolemur garnettii | ENSOGAG00000016871 | 9978 | Ochotona princeps | ENSOPRG00000006441 |
42254 | Sorex araneus | ENSSARG00000006206 | 37347 | Tupaia belangeri | ENSTBEG00000011771 |
9739 | Tursiops truncatus | ENSTTRG00000010250 |